Filter lifetimes of different hemodiafiltration membrane materials in dogs: reevaluation of the optimal anticoagulant dosage

Abstract Background In continuous renal replacement therapy (CRRT), administration of anticoagulants is necessary for achieving a certain level filter lifetime. Generally, anticoagulant doses are controlled to keep activated partial thromboplastin time and other indicators within target range, regardless the membrane materials used filter. However, in actual clinical practice, lifetime varies significantly depending on material used. The objective this study was demonstrate that minimum dose prolonging while reducing risk hemorrhagic complications type membrane. Methods three beagles, hemodiafiltration performed with hemofilters using polysulfone (PS), polymethylmethacrylate (PMMA), AN69ST membranes separately. nafamostat mesylate (NM) would allow 6 h (required dose) investigated each material. Results NM required were 2 mg/kg/h PS membrane, PMMA Conclusion For varied Using optimal safer CRRT performance.